NClass

NClass is a free tool to easily create UML class diagrams with full C# and Java language support.
CollabNet

ArgoUML, free and safe download. ArgoUML latest version: Open-source diagramming application for personal computers. ArgoUML is a program that allows users to create complex and professional diagrams.
Visio

Simplify and communicate complex information using data-linked diagrams.
WhiteStarUML

WhiteStarUML is a fork of StarUML with an intent to revive its Delphi code base by updating code to…
PathVisio

Open-source and free pathway analysis and pathway drawing software. Allows drawing, editing and analysis of biological pathways.
ProtoTouch

Create, Preview, Share and Install in any iPhone iPod iPad or web browser your mobile prototypes…
RagTime

RagTime is both a traditional Office and DTP layout application.
BluePrint UI design

Blueprint is an UI design application for iPad and iPhone.
Umbrello

Umbrello UML Modeller is a Unified Modelling Language diagram programme for KDE.
Eclipse Papyrus

Eclipse Papyrus is an industrial-grade open source Model-Based Engineering tool. Eclipse Papyrus has notably been used successfuly in industrial projects and is the base platform for several industrial modeling tools.